How Our Products Can Treat Cerebral Palsy

We use products derived from human baby umbilical cord tissues in all our therapy programs - Wharton's Jelly MSCs (wjMSCs). The human brain is strictly regulated by the blood-brain barrier (BBB). This is a semipermeable endothelial membrane that separates blood from cerebrospinal fluid. It is a highly selective mechanism that allows only a select few types of cells, particles and molecules enter the brain. Our products are special because they can:

• cross the endothelial brain barrier ^[1,2,3,4].
• migrate to sites of injury (chemotaxis) ^[5,6].
• communicate with and alter nearby cells (paracrine effect) ^[7,8,9].
• encourage existing cells to self-repair (autocrine effect) ^[9,10,11].
• prevent rejection by regulating the immune system (immunomodulation) ^{[5,6,12,13,14,15,16,17,18]}.
• reduce inflammation ^{[6,17,18,19,20,21,23]}.
• prevent cells from dying (apoptosis) ^{[5,6,8,19,24]}.
• transform into neurons and glia ^{[20,24,25,26,27,28]}.
• promote the formation of nerve cell axons (axogenesis) ^[21,22].
• incapable of forming tumours ^[5,14,15,29].
• release neuroprotective factors ^[8,30].
• encourage existing cells to adapt (neuroplasticity) ^[31,32,33].

Treating Cerebral Palsy

In 2013, a collaborative study between Chinese and American universities administered 7 transfusions of wjMSCs over the course of 6 months to a 5-year-old girl with cerebral palsy. She was monitored for 28 consecutive months, at the end of which, the patient had fewer incidents of ambulatory tumbles and the patient was able to sit upright on her own. Her immune system has also gotten stronger and she had increased physical strength, speech and comprehension ^[34].

Two years later, a Chinese pilot study investigated the effects of wjMSCs transplantations on eight (8) pairs of twins (16 individuals). All participants had significant improvement in gross motor function at the end of the 1st and 6th months while some reported improvements in fine motor function as well ^[35].

Most recently in 2018, the Chinese Academy of Medical Sciences reported the case of a 4-year-old boy with cerebral palsy. The patient received 3 doses of wjMSCs, at the end of which, obvious improvements in electroencephalogram (EEG) imaging, limb motor strength, motor function and language expression were noted. However, the patient did not show as promising an improvement in his intelligence quotient (I.Q.) scores ^[36].

Cyrona’s Program

Achieving high standards in our work is of paramount importance to us. Depending on a patient’s needs, we combine our premium grade Passage 2 wjMSCs with physiotherapy, occupational therapy, speech and language therapy and/or rehabilitative medicine. 

Learn more about our Products and Programs.

Why Choose Cyrona?

• Latest cellular research and technology.
• Unique, tailored therapy outlines.
• Products that meet international standards.
• Microbiology & clinical team with extensive experience in advanced medicine.
• Board-certified physicians geared towards patient safety.
• Fact-based information from clinical studies and trials.
• No outlandish promises of a one-stop-cure or false improvement rates.

Therapy Packages

All our therapy packages come inclusive of:

INTERNATIONAL PATIENTS

• Premium grade P1 and P2 wjMSCs.
• Treatment by qualified specialist(s).
• Certificate of Analysis (CoA) authenticating wjMSCs and supplementary transfusion(s).
• Airport transfer.
• Transportation to & from therapy session(s).
• Accommodation.
• Hospital room for therapy.

LOCAL PATIENTS

• Premium grade P1 and P2 wjMSCs.
• Treatment by qualified specialist(s).
• Certificate of Analysis (CoA) authenticating wjMSCs and supplementary transfusion(s).
• Transportation to & from therapy session(s).
• Hospital room for therapy.

How Do We Proceed

In our Cerebral Palsy Therapy Program, the number of wjMSCs required is determined by the age and body weight of the patient. Our specialists prefer to review each patient’s medical reports before tailoring a program that will be most beneficial to the patient.

You may chat with one of our Customer Care Representatives or send an e-mail detailing the patient’s condition to one of our Liaison Officers. It would expedite the process if you can provide us with:

• The age and body weight of the patient.
• Imaging results (MRI scan / CT scan / X-Ray).
• Hematology reports (blood test).
• Doctor’s assessment reports.
• Pictures or videos of the patient (if relevant).

Upon getting in touch with us, a Liaison Officer evaluates and assigns the case to the specialist best equipped to treat the condition. A therapy, unique only to the patient, is drawn up and a price quoted accordingly.

Should you decide to proceed with therapy, our specialists require that all patients have Cancer Marker Screening performed in their country of residence before travelling to us for therapy. If the patient has had Cancer Marker Screening within the last 3 months, you may e-mail those results to us. In the event that the patient’s Cancer Marker Screening results are not satisfactory, our specialists will refuse to proceed with therapy. It is for this reason that we requests that patients have Cancer Marker Screening performed in their country of residence prior to travelling to us.

One week prior to arrival, a deposit payment is required in order to arrange accommodation and transportation.

Full payment is required to be made one-day prior to therapy commencement.

Post-treatment, our specialist will provide the patient with a post-treatment protocol as well as what to expect on his or her journey towards a better, and hopefully, healthier new life.